The "Residenza Sangallo" is located close to Piazza San Marco and the "Academy (home to Michelangelo's David) just 10 minutes on foot from the Duomo

BY CAR: Approach the city center by following signs "viali di circonvallazione". Drive along the tree-lined avenues that are around the city center until you reach PIAZZA DELLA LIBERTA' - turn on VIA CAVOUR - drive for 3 blocks to reach PIAZZA SAN MARCO, turn right (on via degli Arazzieri), then turn right on the first street (Via San Gallo)

FROM THE TRAIN STATION: At the train station you can always find taxis. If you don't have heavy luggage you can walk. It's 15 minutes walking distance. You can also take one of following buses : 1 - 7 - 10 - 17 - 25 . Get off PIAZZA SAN MARCO. Buy bus tickets at the newspaper shop inside the train station.
FROM THE AIRPORT: by taxi or by bus until the train station and from there one of the above mentioned bus.

Google Map